Scientific research and scientific and methodological support in the field of balneology and restorative treatment:
Intellectual Property Objects
The Institute has received a Certificate of Accreditation as a Scientific Activity Entity.
Series MK No. 000200, dated May 24, 2023.
By Order N21-p dated 01.27.2023, the Scientific and Technical Council was established.
Заседания:
№1 от 01.03. 2023 г.
№2 от 28.06.2023 г.
№3 от 26.09.2023 г.
№4 от 21.12.2023 г.
№2 от 28.06.2023 г.
№3 от 26.09.2023 г.
№4 от 21.12.2023 г.
By Order No. 22-p dated 01/31/2023, a Local Ethical Commission was established.
Заседания:
№1 от 07.02.2023 г.
№2 от 15.11.2023 г.
№2 от 15.11.2023 г.
The Scientific and Technical Council of the Research Institute recommended methodological recommendations for publication (Protocol No. 2 of 06/28/2023):
E. K. Kaidar, A. K. Turgambayeva, B. N. Kosherova "management of the organization of medical and social assistance to patients with post-covid syndrome at the level of first medical and sanitary assistance".
E. K. Kaidar, A. K. Turgambayeva, B. N. Kusherova "guidelines for the organization of medical and social care at the level of primary health care for patients with post-Covid syndrome".
Amanbekova A. U., Kairgeldina S. A., Makhmutova A. N., Dosmagambetova R. S. "sanatorium-resort rehabilitation of patients with diabetes".
E. K. Kaidar, A. K. Turgambayeva, B. N. Kusherova "guidelines for the organization of medical and social care at the level of primary health care for patients with post-Covid syndrome".
Amanbekova A. U., Kairgeldina S. A., Makhmutova A. N., Dosmagambetova R. S. "sanatorium-resort rehabilitation of patients with diabetes".
A scientific article by a team of authors has been published in an international peer-reviewed journal with a non-zero impact factor.
-Z. Shulgau; Y. Kamyshanskiy; Sh. Sergazy; A. Zhulikeyeva; A. Urazbayeva, A. Makhmutova; Zh. Bokebayev; A. Gulyayev; Y. Ramankulov. Modeling Mediated Crossover Acute and Subacute Damage to the Pulmonary System During Systemic (Subcutaneous) Administration of Bleomycin in Mice to Test the Potential Therapeutic Effect of Polyphenols. — Int. J. Morphol., 41(6):1837-1845, 2023
A monograph titled "Bioclimatic Potential and Sanatorium-Resort Treatment" has been published.
- Kairgeldina S.A. (Excerpt from the minutes of the NTS meeting No. 2 dated June 28, 2023).
- By Order No. 405 dated 10/15/2024, amendments were made to the order of the Director of the Research Institute of Balneology and Medical Rehabilitation "On the establishment of a Local Ethical Commission on Bioethics" No. 22 dated 01/21/13.
According to Order No. 405:
Chairman of the LEK – Baurzhan Madina Baurzhanovna (PhD)
Secretary of the LEK – Absattarova Karlygash Seitomarovna (PhD)
LEK meetings have been held:
- No. 1 dated October 18, 2024
- No. 2 dated October 18, 2024
- No. 3 dated November 22, 2024
- A scientific article "IMPORTANT Milestones and EVENTS IN THE HISTORY OF Kazakh BALNEOLOGY" has been published in English "Key Milestones and Events in the History of Kazakh Balneology" by the team of authors:
S.A.Kairgeldina, K.O.Tekebaev, M.B.Baurzhan, K.S. Absattarova, N.I. Slivkina.
In the scientific and practical journal "Bulletin of Restorative Medicine" (ISSN: 2078-1962). Issue 6 (December), 2024, DOI: https://doi.org/10.38025/2078-1962-2024-23-6 .
Resume. The radical socio-political and economic changes of the 1990s, as well as the development of scientific and technological progress, had a negative impact on human health. This manifested itself in a decrease in the body's functional capabilities and a deterioration in the functioning of key life support systems. One of the ways to solve these problems in our country is the development of a sanatorium complex. Initially, the resort business in Kazakhstan followed Western experience, but over time, its own, more scientifically based approaches began to form. For a better understanding of the features and state of the Kazakh resort business, it is important to familiarize yourself with its history and development.
- An article was published in the Collection Shipazhay-2024 "Issues of balneology of the Republic of Kazakhstan", by the authors S.A. Kairgeldina, G.Sh. Zhumaeva, K.S. Absattarova on the topic: "Review of the leading rehabilitation centers of the Republic of Kazakhstan and their services".
On December 27, 2024, the National Scientific Council for the priority area of scientific, scientific and technical activities "Science of Life and Health" recommended for financing the application of the Human Rights Foundation IRN BR27199517 on the topic "An integrated approach to medical prevention and rehabilitation of occupational diseases of the bronchopulmonary system of dust etiology", for a total amount of 681,212,663 tenge.
On April 10, 2025, the National Scientific Council for the priority area of scientific, scientific and technical activities "Advanced manufacturing, digital and space technologies" recommended for financing the application of IRN AR27510665 on the topic "Application of artificial intelligence for the early diagnosis of cicatricial laryngeal stenosis in children" for a total amount of 89 174 838 tenge.
At the examination stage, there is an application of IRN AR26103355 on the topic "Determination of the therapeutic potential of exosome-like nanoparticles from strawberries, grapes and blueberries of the metabolic syndrome model" for a total amount of 119,994,645 tenge.
Secretary of the LEK – Absattarova Karlygash Seitomarovna (PhD)
LEK meetings have been held:
- No. 1 dated October 18, 2024
- No. 2 dated October 18, 2024
- No. 3 dated November 22, 2024
- A scientific article "IMPORTANT Milestones and EVENTS IN THE HISTORY OF Kazakh BALNEOLOGY" has been published in English "Key Milestones and Events in the History of Kazakh Balneology" by the team of authors:
S.A.Kairgeldina, K.O.Tekebaev, M.B.Baurzhan, K.S. Absattarova, N.I. Slivkina.
In the scientific and practical journal "Bulletin of Restorative Medicine" (ISSN: 2078-1962). Issue 6 (December), 2024, DOI: https://doi.org/10.38025/2078-1962-2024-23-6 .
Resume. The radical socio-political and economic changes of the 1990s, as well as the development of scientific and technological progress, had a negative impact on human health. This manifested itself in a decrease in the body's functional capabilities and a deterioration in the functioning of key life support systems. One of the ways to solve these problems in our country is the development of a sanatorium complex. Initially, the resort business in Kazakhstan followed Western experience, but over time, its own, more scientifically based approaches began to form. For a better understanding of the features and state of the Kazakh resort business, it is important to familiarize yourself with its history and development.
- An article was published in the Collection Shipazhay-2024 "Issues of balneology of the Republic of Kazakhstan", by the authors S.A. Kairgeldina, G.Sh. Zhumaeva, K.S. Absattarova on the topic: "Review of the leading rehabilitation centers of the Republic of Kazakhstan and their services".
On December 27, 2024, the National Scientific Council for the priority area of scientific, scientific and technical activities "Science of Life and Health" recommended for financing the application of the Human Rights Foundation IRN BR27199517 on the topic "An integrated approach to medical prevention and rehabilitation of occupational diseases of the bronchopulmonary system of dust etiology", for a total amount of 681,212,663 tenge.
On April 10, 2025, the National Scientific Council for the priority area of scientific, scientific and technical activities "Advanced manufacturing, digital and space technologies" recommended for financing the application of IRN AR27510665 on the topic "Application of artificial intelligence for the early diagnosis of cicatricial laryngeal stenosis in children" for a total amount of 89 174 838 tenge.
At the examination stage, there is an application of IRN AR26103355 on the topic "Determination of the therapeutic potential of exosome-like nanoparticles from strawberries, grapes and blueberries of the metabolic syndrome model" for a total amount of 119,994,645 tenge.
Intellectual Property Objects
• Copyright-protected object: “Complex of Plant Adaptogens for Respiratory System Protection” No. 62119, dated 15 September 2025, issued by the National Institute of Intellectual Property.
• Copyright-protected object: “Protocol of a Systematic Review of Sanatorium-Climatic and Hydrotherapy Rehabilitation Programs for Stable COPD and Methodology for Stratifying Rehabilitation Programs” No. 64572, dated 25 November 2025, issued by the National Institute of Intellectual Property.
List of articles published in journals included in the list recommended by the Committee for Quality Assurance in Science and Higher Education of the Ministry of Science and Higher Education of the Republic of Kazakhstan
Methodological Recommendation
Title: “Medical Rehabilitation of Patients with Respiratory Diseases in Sanatorium-Resort Settings”
Authors: S.A. Kairgeldina, N.I. Sheveleva, L.K. Ibraeva, R.S. Dosmagambetova, A.U. Amanbekova, A.E. Gulyayev, K.O. Tekebaev, M.B. Baurzhan. ISBN: 978-601-305-734-7. UDC: 616.2. BBK: 53.59 М42
List of publications published as articles in peer-reviewed journals ranked in the 1st (first), 2nd (second), and/or 3rd (third) quartile by impact factor in the Web of Science database and/or having a CiteScore percentile in the Scopus database
1. Botbayev, D., Sharipov, K., Belkozhayev, A., Alzhanuly, B., Yerkinbek, U., Sharipov, D., Gulyayev, A., Kairgeldina, S., Tekebayev, K., Zhunussova, G., & Baurzhan, M. (2026). Genetic Determinants of Radiosensitivity: Evidence of Radioresistance-Associated SNP Enrichment in Occupational Workers Chronically Exposed to Low-Dose Radiation. Genes, 17(2), 191. https://doi.org/10.3390/genes17020191
2. Demchenko, G., Kairgeldina, S., Baurzhan, M., Abdreshov, S., Kozhaniyazova, U., Nurmakhanova, B. (2026). Effect of a New Phytocompound on the Contractile Activity of Lymph Nodes in Old Animals. Gerontology, Jan 22:1–18. doi: 10.1159/000550446. Epub ahead of print. PMID: 41569960.
3. Kairgeldina, S.A., Tekebaev, K.O., Baurzhan, M.B., Absattarova, K.S., & Slivkina, N.V. (2024). Key Milestones and Events in the History of Kazakh Balneology. Vestnik Vosstanovitel’noy Meditsiny, 23(6), 111–118.
4. Shulgau, Z., Kamyshanskiy, Y., Sergazy, S., Zhulikeyeva, A., Urazbayeva, A., Makhmutova, A., ... & Ramankulov, Y. (2023). Modeling Mediated Crossover Acute and Subacute Damage to the Pulmonary System During Systemic (Subcutaneous) Administration of Bleomycin in Mice to Test the Potential Therapeutic Effect of Polyphenols. International Journal of Morphology, 41(6).
5. Gulyayev, A.E., Absattarova, K.S., Kairgeldina, S.A., Dosmagambetova, R.S., Tekebayev, K.K., Baurzhan, M.B., ... & Dauletova, G.S. (2025). An Integrated Strategy for Preventing and Rehabilitating Dust-Induced Occupational Bronchopulmonary Diseases: A Scoping Review. Advances in Respiratory Medicine, 93(4), 30.
List of articles published in journals included in the list recommended by the Committee for Quality Assurance in Science and Higher Education of the Ministry of Science and Higher Education of the Republic of Kazakhstan
1. Amanbekova, A.U., Grebeneva, O.V., Dosmagambetova, R.S., Shadetova, A.Zh., Alekseev, A.V., Rusyaev, M.V., & Okasov, D.B. (2025). Occupational Features of the Onset and Course of Dust-Related Lung Diseases: Literature Review. Science and Healthcare, 27(2), 219–231.
2. Sheveleva, N.I., Amanbekova, A.U., Dosmagambetova, R.S., Otarov, E.Zh., Grebeneva, O.V., Shadetova, A.Zh., ... & Okasov, D.B. (2025). Principles of Rehabilitation and Prevention of Occupational Dust-Induced Bronchopulmonary Diseases. Medicina i Ekologiya, (3), 27–34. — Included in the list of journals recommended by the Committee for Quality Assurance in Science and Higher Education, Ministry of Science and Higher Education of the Republic of Kazakhstan
3. Kairgeldina, S., Absattarova, K., Baurzhan, M., Tekebaev, K., Abzaliev, K., Abzalieva, S., ... & Suyindik, Q. (2025). Effectiveness of Sanatorium-Resort and Climatic Rehabilitation Interventions for Patients with Stable COPD: Systematic Review and Meta-Analysis. Kazakh National Medical University, 83. — Included in the recommended journal list by the Ministry of Science and Higher Education
4. Adyrakova, R., Baurzhan, M., Tekebaev, K., Kairgeldina, S., Abzaliev, K., Abzaliev, B., Iglikova, A. (2025). Prevalence of Ophthalmopathology among Miners with Occupational Bronchopulmonary Diseases. Astana Medical Journal, 125(5), 2025. https://doi.org/10.54500/2790-1203-2025-5-125-amj006 — Included in the recommended journal list
5. Shulgau, Z., Nurgozhina, A., Sadvokassova, D., Sergazy, Sh., Gulyayev, A. (2025). Geroprotective Potential of Plant and Synthetic Antioxidants. Medicina i Ekologiya, 2(115), 29–41. https://doi.org/10.59598/ME-2305-6053-2025-115-2-29-41 — Included in the recommended journal list
Title: “Medical Rehabilitation of Patients with Respiratory Diseases in Sanatorium-Resort Settings”
Authors: S.A. Kairgeldina, N.I. Sheveleva, L.K. Ibraeva, R.S. Dosmagambetova, A.U. Amanbekova, A.E. Gulyayev, K.O. Tekebaev, M.B. Baurzhan. ISBN: 978-601-305-734-7. UDC: 616.2. BBK: 53.59 М42
List of publications published as articles in peer-reviewed journals ranked in the 1st (first), 2nd (second), and/or 3rd (third) quartile by impact factor in the Web of Science database and/or having a CiteScore percentile in the Scopus database
1. Botbayev, D., Sharipov, K., Belkozhayev, A., Alzhanuly, B., Yerkinbek, U., Sharipov, D., Gulyayev, A., Kairgeldina, S., Tekebayev, K., Zhunussova, G., & Baurzhan, M. (2026). Genetic Determinants of Radiosensitivity: Evidence of Radioresistance-Associated SNP Enrichment in Occupational Workers Chronically Exposed to Low-Dose Radiation. Genes, 17(2), 191. https://doi.org/10.3390/genes17020191
2. Demchenko, G., Kairgeldina, S., Baurzhan, M., Abdreshov, S., Kozhaniyazova, U., Nurmakhanova, B. (2026). Effect of a New Phytocompound on the Contractile Activity of Lymph Nodes in Old Animals. Gerontology, Jan 22:1–18. doi: 10.1159/000550446. Epub ahead of print. PMID: 41569960.
3. Kairgeldina, S.A., Tekebaev, K.O., Baurzhan, M.B., Absattarova, K.S., & Slivkina, N.V. (2024). Key Milestones and Events in the History of Kazakh Balneology. Vestnik Vosstanovitel’noy Meditsiny, 23(6), 111–118.
4. Shulgau, Z., Kamyshanskiy, Y., Sergazy, S., Zhulikeyeva, A., Urazbayeva, A., Makhmutova, A., ... & Ramankulov, Y. (2023). Modeling Mediated Crossover Acute and Subacute Damage to the Pulmonary System During Systemic (Subcutaneous) Administration of Bleomycin in Mice to Test the Potential Therapeutic Effect of Polyphenols. International Journal of Morphology, 41(6).
5. Gulyayev, A.E., Absattarova, K.S., Kairgeldina, S.A., Dosmagambetova, R.S., Tekebayev, K.K., Baurzhan, M.B., ... & Dauletova, G.S. (2025). An Integrated Strategy for Preventing and Rehabilitating Dust-Induced Occupational Bronchopulmonary Diseases: A Scoping Review. Advances in Respiratory Medicine, 93(4), 30.
List of articles published in journals included in the list recommended by the Committee for Quality Assurance in Science and Higher Education of the Ministry of Science and Higher Education of the Republic of Kazakhstan
1. Amanbekova, A.U., Grebeneva, O.V., Dosmagambetova, R.S., Shadetova, A.Zh., Alekseev, A.V., Rusyaev, M.V., & Okasov, D.B. (2025). Occupational Features of the Onset and Course of Dust-Related Lung Diseases: Literature Review. Science and Healthcare, 27(2), 219–231.
2. Sheveleva, N.I., Amanbekova, A.U., Dosmagambetova, R.S., Otarov, E.Zh., Grebeneva, O.V., Shadetova, A.Zh., ... & Okasov, D.B. (2025). Principles of Rehabilitation and Prevention of Occupational Dust-Induced Bronchopulmonary Diseases. Medicina i Ekologiya, (3), 27–34. — Included in the list of journals recommended by the Committee for Quality Assurance in Science and Higher Education, Ministry of Science and Higher Education of the Republic of Kazakhstan
3. Kairgeldina, S., Absattarova, K., Baurzhan, M., Tekebaev, K., Abzaliev, K., Abzalieva, S., ... & Suyindik, Q. (2025). Effectiveness of Sanatorium-Resort and Climatic Rehabilitation Interventions for Patients with Stable COPD: Systematic Review and Meta-Analysis. Kazakh National Medical University, 83. — Included in the recommended journal list by the Ministry of Science and Higher Education
4. Adyrakova, R., Baurzhan, M., Tekebaev, K., Kairgeldina, S., Abzaliev, K., Abzaliev, B., Iglikova, A. (2025). Prevalence of Ophthalmopathology among Miners with Occupational Bronchopulmonary Diseases. Astana Medical Journal, 125(5), 2025. https://doi.org/10.54500/2790-1203-2025-5-125-amj006 — Included in the recommended journal list
5. Shulgau, Z., Nurgozhina, A., Sadvokassova, D., Sergazy, Sh., Gulyayev, A. (2025). Geroprotective Potential of Plant and Synthetic Antioxidants. Medicina i Ekologiya, 2(115), 29–41. https://doi.org/10.59598/ME-2305-6053-2025-115-2-29-41 — Included in the recommended journal list